{"id":1870,"date":"2026-06-24T23:46:17","date_gmt":"2026-06-24T16:46:17","guid":{"rendered":"https:\/\/peptidelab.id\/?post_type=product&#038;p=1870"},"modified":"2026-07-16T15:57:28","modified_gmt":"2026-07-16T08:57:28","slug":"pnc-27-5","status":"publish","type":"product","link":"https:\/\/peptidelab.id\/id\/produk\/pnc-27-5\/","title":{"rendered":"PNC-27 5mg"},"content":{"rendered":"<p class=\"translation-block\">PNC-27 mengandung domain pengikat HDM-2 dari p53 (residu 12\u201326) yang dihubungkan dengan peptida yang dapat menembus membran. PNC-27 berikatan dengan HDM-2 yang diekspresikan secara berlebihan pada membran sel kanker, membentuk kompleks pori transmembran oligomerik yang menyebabkan kematian sel nekrotik secara cepat (\u201cpoptosis\u201d). Mekanisme sekunder melibatkan gangguan langsung pada membran mitokondria. Sel normal tidak memiliki HDM-2 pada membrannya sehingga tidak terpengaruh, terlepas dari status mutasi p53.<\/p>","protected":false},"excerpt":{"rendered":"<p class=\"translation-block\">PNC-27 mengandung domain pengikat HDM-2 dari p53 (residu 12\u201326) yang dihubungkan dengan peptida yang dapat menembus membran. PNC-27 berikatan dengan HDM-2 yang diekspresikan secara berlebihan pada membran sel kanker, membentuk kompleks pori transmembran oligomerik yang menyebabkan kematian sel nekrotik secara cepat (\u201cpoptosis\u201d). Mekanisme sekunder melibatkan gangguan langsung pada membran mitokondria. Sel normal tidak memiliki HDM-2 pada membrannya sehingga tidak terpengaruh, terlepas dari status mutasi p53.<\/p>","protected":false},"featured_media":1883,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[26,21],"product_tag":[],"class_list":{"0":"post-1870","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-cellular-regulation","7":"product_cat-healing-recovery","9":"first","10":"instock","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PNC-27 5mg - Buy Peptides in Jakarta | Same-Day Delivery | Peptide Lab<\/title>\n<meta name=\"description\" content=\"&quot;PNC-27 contains the p53 HDM-2-bindingdomain (residues 12-26) linked to a membrane-penetrating peptide. It binds HDM-2overexpressed on cancer cell membranes,forming oligomeric transmembrane porecomplexes that cause rapid necrotic cell death(&#039;poptosis&#039;). A secondary mechanism involvesdirect mitochondrial membrane disruption.Normal cells lack membrane HDM-2 and areunaffected, regardless of p53 mutation status.&quot;\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/peptidelab.id\/id\/produk\/pnc-27-5\/\" \/>\n<meta property=\"og:locale\" content=\"id_ID\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PNC-27 5mg - Buy Peptides in Jakarta | Same-Day Delivery | Peptide Lab\" \/>\n<meta property=\"og:description\" content=\"&quot;PNC-27 contains the p53 HDM-2-bindingdomain (residues 12-26) linked to a membrane-penetrating peptide. It binds HDM-2overexpressed on cancer cell membranes,forming oligomeric transmembrane porecomplexes that cause rapid necrotic cell death(&#039;poptosis&#039;). A secondary mechanism involvesdirect mitochondrial membrane disruption.Normal cells lack membrane HDM-2 and areunaffected, regardless of p53 mutation status.&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/peptidelab.id\/id\/produk\/pnc-27-5\/\" \/>\n<meta property=\"og:site_name\" content=\"Buy Peptides in Jakarta | Same-Day Delivery | Peptide Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-16T08:57:28+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/peptidelab.id\/wp-content\/uploads\/2026\/06\/Peptide_Lab-14E-PNC27-50mg.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimasi waktu membaca\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 menit\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/peptidelab.id\\\/product\\\/pnc-27-5\\\/\",\"url\":\"https:\\\/\\\/peptidelab.id\\\/product\\\/pnc-27-5\\\/\",\"name\":\"PNC-27 5mg - Buy Peptides in Jakarta | Same-Day Delivery | Peptide Lab\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/peptidelab.id\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/peptidelab.id\\\/product\\\/pnc-27-5\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/peptidelab.id\\\/product\\\/pnc-27-5\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/peptidelab.id\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/Peptide_Lab-14E-PNC27-50mg.jpg\",\"datePublished\":\"2026-06-24T16:46:17+00:00\",\"dateModified\":\"2026-07-16T08:57:28+00:00\",\"description\":\"\\\"PNC-27 contains the p53 HDM-2-bindingdomain (residues 12-26) linked to a membrane-penetrating peptide. 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