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PNC-27 5mg

PNC-27 5mg

Rp 1,980,000

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PNC-27 5mg
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IKHTISAR SENYAWA

“PNC-27 contains the p53 HDM-2-binding
domain (residues 12-26) linked to a membrane-
penetrating peptide. It binds HDM-2
overexpressed on cancer cell membranes,
forming oligomeric transmembrane pore
complexes that cause rapid necrotic cell death
(‘poptosis’). A secondary mechanism involves
direct mitochondrial membrane disruption.
Normal cells lack membrane HDM-2 and are
unaffected, regardless of p53 mutation status.”

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